000			02173 a2200157 4500
003			DZ-ElOued
005			20260602171329.0
100	1		_aBayou, Samir
700	1		_aBOUKHALLOUT, Fath Eddine
245	0	0	_aSynthèse, Caractérisation Structurale et Activité Biologique des Analogues de la Purine et la Pyrimidine
260			_b _c2025
500			_aSynthèse, Caractérisation Structurale et Activité Biologique des Analogues de la Purine et la Pyrimidine
520			_aHeterocyclic nitrogen systems, such as pyrimidine, purine, imidazole and pyrrole, are found in many natural [ 2 ] and synthetic substances with diverse biological activities. These substances are strategic targets for the development of new therapeutic agents. As part of our project, we aim to synthesise new heterocyclic analogues and study their antioxidant and antibacterial properties. In the first part, we developed the synthesis of new pyrimidine and purine derivatives by carrying out nucleobase (cytosine, adenine and guanine) condensation and cyclisation reactions under basic conditions with electrophilic agents such as 4-bromoacetophenone, benzoin, curcumin and pyrimidine-4,5-dicarboxylate. In the second part, we evaluated the antioxidant and antimicrobial activity of the synthesised products. In vitro evaluation of antioxidant activity was carried out using the DPPH and ABTS radical reduction method. Overall, the results show that the molecules evaluated have real antioxidant capacity, with some of them even displaying greater activity than standard antioxidants, such as ascorbic acid and BHT. The in vitro assessment of antimicrobial activity was carried out using the disc or well diffusion technique. The results obtained indicate that the products evaluated are sensitive to certain micro-organisms. The structural determination of the synthesised heterocycles was carried out using various IR, 1H NMR and 13C NMR spectroscopic methods, and was confirmed by elemental analysis
650		4	_a/Synths̈e//Caractřisation//Structurale//et//Activit/̌/Biologique//des//Analogues//de//la//Purine//et//la//Pyrimidine/
942			_cTHESIS
999			_c18572 _d18572