000			01716 a2200157 4500
003			DZ-ElOued
005			20260602171416.0
100	1		_aAbdelbaki, halla
700	1		_aDjemoui, Amar
245	0	0	_aSynthèse et Activité de Quelques Hétérocycles Azotés
260			_b _c2025
500			_aSynthèse et Activité de Quelques Hétérocycles Azotés
520			_aIn this study, we synthesized 1,2,3-triazoles via a one-pot, multi-component reaction using Cu2O microbeads as catalysts, enhancing reaction conditions and yields (33-85%). The Cu2O microbeads were synthesized in a green environment using an aqueous extract of Artemisia campestris L., resulting in a flower-like morphology with a cubic close-packed crystal structure and a particle size of 3-6 ?m. Following triazole synthesis, we created thiosemicarbazone intermediates with moderate to good yields (32-74%) by condensing triazoles with thiosemicarbazide, allowing for thiazole derivatives formation in moderate to exceptional yields (21-86%), by their condensation with chloroacetone that expands their pharmacological applications. Finally, we evaluated the antioxidant activity of the synthesized products (triazoles, thiosemicarbazones, and thiazoles) using standard radical scavenging assays (DPPH and ABTS) to assess their therapeutic potential against oxidative stress-related diseases. These compounds exhibit significant antioxidant properties. The structures of the synthesized compounds were confirmed using 13C NMR, 1H NMR, and FTIR techniques.
650		4	_a/Synths̈e//et//Activit/̌/de//Quelques//Hťřocycles//Azotš/
942			_cTHESIS
999			_c19452 _d19452